BDBM207624 US10501467, Example 69::US9260440, 69::US9617273, Example 69

SMILES C[C@]12CCCN1Cc1n[nH]c(=O)c3cc(F)cc4[nH]c2c1c34

InChI Key InChIKey=HNHYFXQIDONXEC-MRXNPFEDSA-N

Data  35 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 207624   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM207624(US10501467, Example 69 | US9260440, 69 | US9617273...)
Affinity DataIC50:  766nMAssay Description:Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM207624(US10501467, Example 69 | US9260440, 69 | US9617273...)
Affinity DataIC50:  7.66E+5nMAssay Description:Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM207624(US10501467, Example 69 | US9260440, 69 | US9617273...)
Affinity DataIC50:  7.66E+5nMAssay Description:Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM207624(US10501467, Example 69 | US9260440, 69 | US9617273...)
Affinity DataIC50:  140nMAssay Description:Inhibition of TNKS-2 (unknown origin) pre-incubated for 30 mins before addition of NAD by chemiluminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed